产品货号：
Z39498
中文名称：
PTEN抗体(N-term)
英文名称：
Anti-PTEN Antibody(N-term)(Clone#1096CT4.3.3)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PTEN Antibody (N-term) (Clone#1096CT4.3.3) |
| 指标别名 | 10q23del;Bannayan Zonana syndrome;BC005821;BZS;ITGA 2;MGC11227;MHAM;MMAC1;Multiple hamartoma (Cowden syndrome);phosphatase and tensin homolog;PTEN;PTEN1;TEP1 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | PTEN |
| 克隆号 | 1096CT4.3.3 |
| 抗体来源 | Mouse |
| 免疫原 | This PTEN antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 10-44 amino acids from the N-terminal region of human PTEN. |
| 计算分子量 | 47kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Tumor suppressor.Acts as a dual-specificity protein phosphatase,dephosphorylating tyrosine-,serine- and threonine- phosphorylated proteins.Also acts as a lipid phosphatase,removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate,phosphatidylinositol 3,4-diphosphate,phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns (3,4,5)P3> PtdIns (3,4)P2> PtdIns3P> Ins (1,3,4,5)P4.The lipid phosphatase activity is critical for its tumor suppressor function.Antagonizes the PI3K- AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival.The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation.Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation.Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis,including correct neuron positioning,dendritic development and synapse formation.May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.The nuclear monoubiquitinated form possesses greater apoptotic potential,whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.In motile cells,suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. |
| Uniprot ID | P60484 |
相关搜索：PTEN抗体(N-term)，PTEN单抗，Anti-PTEN Antibody(N-term)(Clone#1096CT4.3.3)